Long term results of high dose vancomycin loaded spacers for treating infected massive prostheses

Poster spacer ciment athenes 2019-2               Delepine F, Alkhallaf S. Delepine G.



infection is of the most devastating complication of conservative surgery using massive prosthesis, leading frequently to amputation. The aim of this bi centric study is to precise the influence of spacer loaded with high doses of vancomycin on late results


Patients From 1984 to 2010, we operated more than 670 patients with bone sarcoma. Aged 4,5 to 82 years (mean 25 y). Histology was osteosarcoma (330), Ewing (175), chondrosarcomas (148), fibrosarcomas or MFH (23), giant cell tumours in others. In 502 cases, p received chemotherapy, and radiotherapy in 50 cases. The median follow-up from tumour removal is 20.5 years. 62 p suffered of deep infection of the material used to reconstruct the skeletal defect. 3 p were refered to us for recurrence of deep infection initially treated elsewhere. Altogether, we treated 65 patients for deep infections.

Method 28 p had debridment and cleaning of the prosthesis and long adapted antibiotherapy as first treatment. When ineffective (25/28), a removal of the prosthesis was performed with immediate re insertion of prosthesis in 19 cases. When infection recurred (16/19) and in 34 other patients the treatment included a two stages protocol with interposition of a spacer with antibiotic loaded cement during 4 to12 weeks .Until 2004, the spacer was made with gentamycin containing palacos mixed with conventional doses of antibiotics adapted to the germ. From 2004/6 we used high doses of vancomycin (4 g per batch of 40 g) with an average total dose of 11g of vancomycin per spacer. The new prosthesis was replaced secondarly when infection, cutaneous and muscular problems were solved.

RESULTS : At last control, 16 were amputated, following a mean of 6 ineffective procedures. 46 p. benefited from conservation surgery but a new prosthesis could be inserted only in 43, following a mean of 3.2 surgical procedures. Analysis shows the very bad prognostic value of initial radiotherapy, of distal locations, the importance of muscular coverage and the efficacy of high dose vancomycin in spacer. Up to date, none of the high dose vancomycin loaded spacers was followed by amputation

CONCLUSION Infection of massive prostheses is the most serious orthopaedic complication of limb salvage. Treatment must be preventive, avoiding any radiotherapy. Good prognostic factors of deep infection are early removal of the prosthesis, improvement of the muscular coverage, and use of spacers with high dose vancomycin.



ISOLS2019 long term follow up of acetabular prostesis for malignancies


Very long-term follow-up of composite prostheses after periacetabular resection.

Fabrice Delépine, Gérard Delépine


Materials and methods.

The “hand on innominate prosthesis” described by us in 2003 (Sarcoma 2003) is made of a titanium cup, a set of long titanium screws and 2 or 3 packs of antibiotics loaded cement. To evaluate the orthopedic results of the implants, we take in account the score at last local control. We use the numerical rating assessing each of the seven variables of the MSTS system on a five-point scale, giving a maximum score of 35 points, recorded as 100 %. Between 1990-2007, 84 patients (p) with peri acetabular bone sarcoma (40), metastases (44) were treated by internal hemipelvectomy followed by this reconstructive procedure. 23 survivors (20/40 sarcomas, 3/44 metastases) have been followed more than 5 years. Histology of 23: chondrosarcoma: 8, osteosarcoma:5, Ewing: 5, MFH: 1, anaplasic sarcoma :1, renal cell carcinoma 2, thyroid 1. Resection included 4 zone 2, 6 zone 2+3, 9 zones 2+1, 3 zones 2+1+4, and 1, zones 1+2+3.


Median FU of these 23 p is 18,5 years (133- 301 months). Postoperative complications included 1 deep infection, 6 hip prosthesis dislocations (26%), 2 neurologic palsies. Late complications were 2 deep infections, 8 polyethylene wears and 8 loosening (5 iliac, 3 femoral). 17 p (73 %) had to be re operated. The type of orthopedic complications is significantly correlated with the topography of the resection: loosening of the iliac prosthesis threatens only resection of zone 1.

The mean functional result, rated according modified Ennecking’s grading system, was 80%. Result similar to those described in the literature for custom made innominate prosthesis and better than those of published alternative reconstructive procedures.



The immediate weight bearing and the durability of such a procedure plea for using it after acetabulum resection of zone 2 and 3 (we did not observe loosening of the iliac reconstruction). Such a procedure can also be used after total iliac wing resection, even when including zone 4. But in this location loosening is frequent and pleas for reinforcing the reconstruction with the head and neck of femur when there are free of tumor as advocated by Puget (RCO 2012)